I have published article comparing TIScript and JavaScript on CodeProject. That is a “big picture” if you wish.
I have written this article completely in the ScApp (Sciter Application) named BlockNote for the Net: 
It is a part of Sciter SDK and reside in sdk/scapps/blocknote.net/ folder.
Eventually this will replace outdated BlockNote v.1.8 application. Plan is to create platform for comfortable content editing in Internet. E.g. as an editor it is already more convenient than built-in editor of the WordPress application I am using here.
Can you post more information TIScript please.
More information including language specification: http://code.google.com/p/tiscript/